Related Experiment Video
Updated: Sep 13, 2025

Author Spotlight: Repetitive Transcranial Magnetic Stimulation Combined with Movement Observation in Cerebral Palsy
Published on: August 9, 2024
An Orthopedic Perspective on the Management of Spasticity
Mary Lou1, Ashley Knebel1, Jacob Eberson2
1Department of Orthopaedic Surgery, Brown University, Warren Alpert Medical School, Providence, RI.
Spasticity from upper motor neuron injury can cause deformities and impair function. Treatment options range from nonoperative methods to orthopedic surgery for improved mobility and independence.
Area of Science:
- Neurology
- Orthopedic Surgery
- Rehabilitation Medicine
Background:
- Neurologic conditions like stroke and cerebral palsy injure upper motor neurons, leading to spasticity.
- Spasticity causes hypertonicity and muscle imbalance, resulting in deformities that impair function and lead to complications.
- Effective management of spasticity is crucial for patient outcomes.
Purpose of the Study:
- To review the management of spasticity resulting from upper motor neuron injury.
- To discuss nonoperative and surgical treatment options for spasticity.
- To highlight the benefits of spasticity management on patient function and independence.
Main Methods:
- Review of nonoperative techniques including physiotherapy, bracing, and medications.
- Discussion of surgical interventions such as intrathecal baclofen pumps, selective dorsal rhizotomy, and orthopedic surgeries.
- Analysis of treatment efficacy in controlling spasticity and correcting deformities.
Main Results:
- Nonoperative methods offer symptom management for spasticity.
- Intrathecal baclofen pumps and selective dorsal rhizotomy show efficacy in spasticity control.
- Orthopedic surgery effectively corrects deformities in refractory spasticity cases.
Conclusions:
- A spectrum of treatments exists for spasticity, from conservative to surgical.
- Surgical interventions provide options for spasticity that has not responded to nonoperative management.
- Successful spasticity treatment improves patient mobility, reduces pain, and enhances independence.
Related Concept Videos
Spasmolytic Agents: Chemical Classification
A major class of centrally acting spasmolytics is the α2-agonist, such as tizanidine. These drugs bind to α2-adrenoceptors, inhibiting the release of the excitatory neurotransmitter glutamate. They also...
Peripheral Artery Disease IV: Nursing Management
Centrally Acting Muscle Relaxants: Therapeutic Uses
Centrally acting drugs are classified into spasmolytic and antispasmodic drugs. Spasmolytic drugs such as baclofen, diazepam, and tizanidine inhibit spinal motor neurons and decrease muscle tone. Spasmolytic drugs are administered for severe and chronic spasms due to multiple sclerosis, cerebral palsy, stroke, and spinal cord and muscle injuries. However,...
Skeletal Muscle Relaxants: Therapeutic Uses

