Related Experiment Video
Updated: Sep 13, 2025

Purification and Visualization of Lipopolysaccharide from Gram-negative Bacteria by Hot Aqueous-phenol Extraction
Published on: May 28, 2012
Advances in Helicobacter pylori lipopolysaccharide structure and function
Xiaoqiong Tang1,2, Alfred Tay3, Mohammed Benghezal1,2
1Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
None:
Helicobacter pylori is a widespread pathogen responsible for chronic gastritis, peptic ulcers, and an elevated risk of gastric cancer. Lipopolysaccharide (LPS), localized exclusively in the outer leaflet of the outer membrane, is essential for maintaining bacterial integrity. Recent advances have deepened our understanding of H. pylori LPS structure, particularly lipid A modifications and the redefinition of the core oligosaccharide and O-antigen regions. The complete set of enzymes involved in LPS biosynthesis has been identified in the reference strain G27, and comparative genomics has revealed a notable regional difference (the absence of the heptan domain in East Asian strains). Here, we summarize recent insights into the structure and function of H. pylori LPS, emphasizing its role in bacterial persistence and its promise as a target for LPS-based glycoconjugate vaccine development.
More Related Videos
09:05High Resolution Electron Microscopy of the Helicobacter pylori Cag Type IV Secretion System Pili Produced in Varying Conditions of Iron Availability
Published on: November 21, 2014
10:59Enrichment of Bacterial Lipoproteins and Preparation of N-terminal Lipopeptides for Structural Determination by Mass Spectrometry
Published on: May 21, 2018
Related Concept Videos
Formation of Lipopolysaccharides
Outer Layers of the Cell Envelope
Peptidoglycan Synthesis
Archaeal Cell Wall
Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy
Bacterial Cell Wall