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Updated: Sep 13, 2025

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Comparing Clinical Practice to Calculated Risks: A Retrospective Study on Early-onset Neonatal Sepsis in a Level-1

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  • 1From the Departamento de Pediatría.

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|July 28, 2025
PubMed
Summary
This summary is machine-generated.

The Kaiser Permanente neonatal sepsis calculator aids in managing early-onset neonatal sepsis (EONS). Adjusting its screening threshold improved sepsis identification and correlated with shorter hospital stays and lower costs.

Keywords:
antibiotic stewardship in neonatesearly-onset neonatal sepsissepsis risk assessment

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Area of Science:

  • Neonatal Medicine
  • Pediatric Infectious Diseases
  • Healthcare Management

Background:

  • Early-onset neonatal sepsis (EONS) is a leading cause of infant morbidity and mortality.
  • Traditional EONS assessment relies on categorical risk factors.
  • The study evaluates the Kaiser Permanente neonatal sepsis calculator's impact on newborn management.

Purpose of the Study:

  • To assess the current incidence of EONS.
  • To evaluate the effectiveness of the Kaiser Permanente neonatal sepsis calculator in managing newborns.
  • To determine the impact of calculator-guided management on clinical practice and resource utilization.

Main Methods:

  • Retrospective study of 4782 live births from 2017-2022.
  • Identification of high-risk newborns using ICD-9 codes and blood culture results.
  • Comparison of Kaiser Permanente calculator recommendations with actual clinical management.

Main Results:

  • Confirmed clinical sepsis incidence was 0.84 per 1000 live births among high-risk infants.
  • Lowering the calculator's screening threshold enhanced sepsis case identification without significantly increasing interventions.
  • Adherence to modified calculator recommendations correlated with shorter hospital stays (2.5 vs. 2.9 days) and reduced costs (884.1€ vs. 1075.1€).

Conclusions:

  • The Kaiser Permanente calculator is effective for asymptomatic newborns but requires modification for infants with clinical signs.
  • Adjusted calculator use shows potential for optimizing resource allocation in neonatal care.
  • Modified calculator recommendations can lead to improved clinical outcomes and cost-effectiveness.