Mycosis fungoides: a review
Charlotte Sheern1, Nick J Levell1,2, Paul J Craig3
1Norwich Medical School, University of East Anglia, Norwich, UK.
Clinical and Experimental Dermatology
|July 28, 2025
Summary
Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma (CTCL). This review covers MF
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Mycosis fungoides (MF) is the most common type of cutaneous lymphoma, accounting for 60% of CTCL diagnoses.
- MF presents in patch, plaque, and tumor stages, often mimicking eczema or psoriasis, making diagnosis challenging.
- The etiology of MF remains largely unknown despite extensive research.
Purpose of the Study:
- To provide a comprehensive overview of mycosis fungoides.
- To discuss the epidemiology, clinical features, diagnostic challenges, and management strategies for MF.
Main Methods:
- Review of existing literature on mycosis fungoides.
- Clinicopathological correlation for diagnosis, often requiring multiple skin biopsies.
- Overview of first-line and advanced treatment modalities.
Main Results:
- MF diagnosis requires careful clinicopathological correlation, especially in early patch stages.
- Skin-directed therapies (SDT) like topical corticosteroids and phototherapy are first-line treatments.
- Systemic therapies, radiotherapy, and stem cell transplant are options for refractory or advanced disease.
Conclusions:
- Mycosis fungoides is a complex cutaneous lymphoma with challenging diagnosis and varied management options.
- Early diagnosis and appropriate treatment are crucial, as MF can progress to involve extracutaneous organs.
- Continued research into MF etiology and novel therapies is essential.
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