Related Experiment Video
Updated: Sep 13, 2025
09:45
Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease
Published on: April 12, 2021
8.4K
Emerging roles of epigenetic regulators during lung development
Guohua Meng1, Wenli Yin1, Yue Hong2
1School of Life and Health Sciences, Hainan Province Key Laboratory of One Health, Collaborative Innovation Center of Life and Health, Hainan University, Haikou, Hainan, China.
Cell Death & Disease
|July 28, 2025
Summary
Epigenetic regulators control gene expression crucial for lung development. Understanding their changes in disease offers new therapeutic targets for fetal lung diseases.
Area of Science:
- Developmental biology
- Epigenetics
- Pulmonology
Background:
- Epigenetic pathways (DNA methylation, non-coding RNAs, histone modification, chromatin remodeling) regulate gene expression during embryogenesis.
- Epigenetic regulators are essential for normal lung development.
- Altered epigenetic marks in lung cells are observed during disease progression.
Purpose of the Study:
- To review recent findings on how epigenetic regulator levels and patterns change during lung development.
- To elucidate the role of these regulators in various stages of lung development.
- To identify potential therapeutic targets for fetal lung diseases.
Main Methods:
- Literature review of recent studies on epigenetic regulators in lung development.
- Analysis of how epigenetic regulator expression and function are altered in lung development and disease.
- Synthesis of current knowledge on epigenetic mechanisms in lung embryogenesis.
Main Results:
- Epigenetic regulators are dynamically modulated throughout lung development.
- Specific epigenetic alterations are associated with abnormal lung development and disease.
- These regulators impact key developmental processes including branching morphogenesis and cell differentiation.
Conclusions:
- Epigenetic mechanisms play a critical role in orchestrating lung development.
- Dysregulation of epigenetic regulators contributes to fetal lung diseases.
- Targeting epigenetic pathways presents a promising strategy for treating lung developmental disorders.
Related Concept Videos
01:46Epigenetic Regulation
31.4K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
31.4K
02:23Master Transcription Regulators
7.1K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
7.1K
02:36RNA Polymerase II Accessory Proteins
9.5K
Proteins that regulate transcription can do so either via direct contact with RNA Polymerase or through indirect interactions facilitated by adaptors, mediators, histone-modifying proteins, and nucleosome remodelers. Direct interactions to activate transcription is seen in bacteria as well as in some eukaryotic genes. In these cases, upstream activation sequences are adjacent to the promoters, and the activator proteins interact directly with the transcriptional machinery. For example, in...
9.5K
01:22Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
2.3K
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
2.3K
02:30Genomic Imprinting and Inheritance
35.3K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
35.3K
01:24Methods of Nuclear Reprogramming
1.9K
Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for...
1.9K