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Aging01:26

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Updated: Sep 13, 2025

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Liver, ageing and disease.

David G Le Couteur1,2,3, Meng C Ngu4,5, Nicholas J Hunt4,5

  • 1ANZAC Research Institute, University of Sydney, Sydney, New South Wales, Australia. david.lecouteur@sydney.edu.au.

Nature Reviews. Gastroenterology & Hepatology
|July 28, 2025
PubMed
Summary
This summary is machine-generated.

Aging significantly impacts liver health and function in older adults, affecting disease development and treatment. Understanding these age-related liver changes is crucial for improving clinical care and exploring new therapeutic strategies.

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Area of Science:

  • Gerontology
  • Hepatology
  • Molecular Biology

Background:

  • Historically, the liver was considered resistant to significant age-related changes.
  • Emerging research indicates substantial age-related alterations in liver pathophysiology at both organ and cellular levels.

Purpose of the Study:

  • To review age-related changes in the liver with significant biological and clinical consequences for older adults.
  • To highlight the implications of liver aging for understanding common liver diseases in the elderly.

Main Methods:

  • Review of current scientific literature on liver aging.
  • Analysis of age-related changes in liver cell types and organ function.
  • Examination of clinical implications for managing liver disease in older populations.

Main Results:

  • Aging profoundly affects liver pathophysiology, impacting organ and cellular functions.
  • Age-related liver changes contribute to diseases like hepatocellular carcinoma and metabolic dysfunction-associated steatotic liver disease.
  • Clinical management now emphasizes age-specific factors like frailty and polypharmacy.

Conclusions:

  • Liver aging has significant biological and clinical consequences, impacting systemic health.
  • Targeting aging biology may offer novel therapeutic avenues for liver diseases in older adults.
  • A deeper understanding of liver aging is essential for advancing geriatric hepatology.