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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Related Experiment Video

Updated: Sep 13, 2025

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
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K-Edge-Inspired Selenomelanin Hydrogel: An X-Ray Filtering Biomaterial for Skin Protection in Radiotherapy.

Hanjie Zhu1,2, Wei Chen3, Ruotong Deng1

  • 1Key Laboratory of Radiopharmaceuticals of the Ministry of Education, College of Chemistry, Beijing Normal University, Beijing, 100875, China.

Advanced Materials (Deerfield Beach, Fla.)
|July 29, 2025
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Summary

A novel X-ray filtering skin dressing, SeMNPs@Car, effectively shields low-energy photons causing radiation dermatitis (RD) while preserving therapeutic radiation dose. This innovation significantly prevents skin ulceration in animal models.

Keywords:
hydrogelmelaninphysical shieldingseleniumskin radioprotection

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Area of Science:

  • Biomaterials Science
  • Radiotherapy Physics
  • Nanotechnology

Background:

  • Radiation dermatitis (RD) is a common side effect of radiotherapy.
  • Current treatments focus on symptom management, not skin dose reduction.
  • Existing shielding materials are inefficient or attenuate therapeutic radiation.

Purpose of the Study:

  • To develop an energy-selective X-ray filter for reducing skin dose during radiotherapy.
  • To create a novel skin dressing that minimizes radiation dermatitis.
  • To investigate the use of selenium-containing melanin nanoparticles in a hydrogel for targeted X-ray shielding.

Main Methods:

  • Integration of selenium-containing melanin nanoparticles (SeMNPs) into a carbomer hydrogel.
  • Development of an X-ray filtering skin dressing (SeMNPs@Car).
  • Evaluation of shielding efficiency for low-energy (10-20 keV) and high-energy photons.
  • Testing in radiation dermatitis animal models and Monte Carlo simulations.

Main Results:

  • SeMNPs@Car achieved 96% shielding of 10-20 keV X-rays and >98% transmission of therapeutic photons.
  • 100% prevention of ulceration and longest delay (≈20 days) in RD onset in animal models.
  • Demonstrated clinical applicability through Monte Carlo simulations.

Conclusions:

  • The SeMNPs@Car dressing offers an effective strategy for energy-selective X-ray shielding.
  • This approach significantly reduces radiation dose to the skin, preventing radiation dermatitis.
  • The study provides insights for developing soft-material X-ray filters for improved radiotherapy outcomes.