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Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
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The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
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Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
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Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
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Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
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First Episode Psychosis in Patients Aged 18 to 30 Admitted Involuntarily: Characteristics and Risk Factors for

Maria El Helou1, Matthieu Hein1,2, Beni-Champion Cimpaye1

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Prolonged duration of untreated psychosis (DUP) and psychosocial vulnerabilities significantly predict poor functional outcomes in young adults with first episode psychosis (FEP) requiring involuntary hospitalization. Early intervention is crucial for better recovery.

Keywords:
duration of untreated psychosisearly interventionfirst-episode psychosisfunctional remissioninvoluntary hospitalizationrisk factors

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Area of Science:

  • Psychiatry
  • Clinical Psychology
  • Public Health

Background:

  • First episode psychosis (FEP) in young adults often necessitates involuntary hospitalization.
  • Understanding factors influencing functional remission is critical for early intervention.
  • Psychosocial vulnerabilities and duration of untreated psychosis (DUP) are key areas of investigation.

Purpose of the Study:

  • To explore clinical and psychosocial predictors of functional non-remission in young adults with FEP.
  • To investigate the specific roles of DUP and contextual vulnerabilities in treatment outcomes.
  • To identify targets for improving functional recovery in this population.

Main Methods:

  • Retrospective monocentric study of 123 young adults (18-30) with FEP.
  • Data extracted from medical records included sociodemographic, clinical, and care-related factors.
  • Functional remission defined by Global Assessment of Functioning (GAF) ≥70; logistic regression used for analysis.

Main Results:

  • Only 48.8% of patients achieved functional remission at discharge.
  • Social isolation, low socioeconomic status, unemployment, lack of activities, and DUP ≥ 4 weeks were associated with non-remission.
  • DUP ≥ 4 weeks independently predicted functional non-remission.

Conclusions:

  • Involuntary admission was not a direct predictor of poor functional outcome.
  • Prolonged DUP and psychosocial vulnerability are critical determinants of early psychosis trajectory.
  • Early detection, integrated psychosocial support, and tailored care planning are essential for improving outcomes in FEP.