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Published on: May 3, 2018
Crosstalk Between Metabolic Biomarkers and Pulse Wave Analysis in Hypertensive Patients
Mirela Baba1,2, Mihaela Ioana Maris2,3, Adina Bucur2,4
1Doctoral School, "Victor Babeş" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Insights
Hypertension is linked to vascular changes and lipid metabolism. This study found that lipid profiles and metabolic biomarkers correlate with pulse wave analysis, aiding early detection of vascular injury in hypertensive patients.
Area of Science:
- Cardiology
- Metabolic Syndrome Research
- Vascular Biology
Background:
- Hypertension is associated with altered vascular function and lipid metabolism.
- Understanding these links is crucial for managing cardiovascular risk.
Purpose of the Study:
- To investigate the relationship between lipid profiles, metabolic biomarkers, and pulse wave analysis in hypertensive patients.
- To assess the utility of these markers in identifying vascular changes.
Main Methods:
- Pulse wave analysis was performed on 66 hypertensive patients using an oscillometric device.
- Serum lipid biomarkers (total cholesterol, triglycerides, non-HDL cholesterol) and lipid balance index (LBI) were measured.
- Associations with metabolic syndrome, insulin resistance, and non-alcoholic fatty liver disease (NAFLD) were analyzed.
Main Results:
- Systolic blood pressure (SBP), diastolic blood pressure (DBP), and early vascular aging (EVA) showed correlations with lipid biomarkers.
- Metabolic syndrome, insulin resistance, and NAFLD were significantly linked to pulse wave analysis variables.
- Total cholesterol (TC) remained significantly associated with DBP in regression analysis.
Conclusions:
- Lipid profiles (TC, TG, non-HDL, LBI) provide insights into blood pressure and EVA in hypertension.
- LBI is valuable for assessing vascular health in hypertensive patients with cardiovascular risk factors, EVA, insulin resistance, and NAFLD.
- Integrating metabolic biomarkers and pulse wave measurements offers a comprehensive approach for early vascular injury detection and cardiovascular event prediction.
Abstract:
Background/Objectives: Hypertension is strongly linked to changes in vascular function and lipid metabolism. This study aimed to examine the relationship between lipid profiles, various metabolic biomarkers, and pulse wave analysis in patients with hypertension. Methods: A group of 66 hypertensive patients, aged 64 ± 10 years, participated in pulse wave analysis utilizing an oscillometric device. Multiple lipid serum biomarkers were assessed, such as total cholesterol (TC), triglycerides (TG), and non-HDL cholesterol (non-HDL). Lipid balance index (LBI) was determined by considering TG, LDL, HDL levels, and lipid-lowering medications. Results: Notable correlations were observed for SBP, DBP, and early vascular aging (EVA) with lipid biomarkers. In addition to serum lipids, metabolic syndrome, insulin resistance, and non-alcoholic fatty liver disease (NAFLD) were significantly linked to pulse wave analysis variables. Multiple regression analysis showed that only TC continued to have a significant association with DBP. Conclusions: Total cholesterol, triglycerides, non-HDL cholesterol, and lipid balance index provide information about systolic and diastolic blood pressure, as well as early vascular aging in hypertensive patients. LBI offers valuable vascular insights in hypertensive individuals with cardiovascular risk factors, early vascular aging, insulin resistance, and NAFLD. The connection between metabolic biomarkers and pulse wave measurements in individuals with hypertension offers a comprehensive method for the early identification of vascular injury and could enhance the prediction of major cardiovascular events.
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Monitoring Both Arms:
Monitoring BP in both arms during the initial assessment is advisable, as the systolic value may differ by five to ten mm Hg between arms. For subsequent BP assessments, use the arm with the higher reading.