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Cartilage-Specific 18F-NaF Uptake in Rat Models: A Multimodal In Vitro and Ex Vitro Comparative Study with 99mTc-MDP.

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  • 1Department of Nuclear Medicine, The First Medical Centre, Chinese PLA General Hospital, Beijing 100853, China.

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|July 29, 2025
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Fluoride-18 sodium fluoride (¹⁸F-NaF) shows better bone and cartilage imaging characteristics than Technetium-99m methylene diphosphonate (⁹⁹mTc-MDP). ¹⁸F-NaF uptake in cartilage depends on cellular activity and calcification, aiding musculoskeletal imaging.

Keywords:
18F-NaF99mTc-MDPbone imagingcalcificationearly osteoarthritismultimodal imaging

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Area of Science:

  • Molecular imaging
  • Radiochemistry
  • Biomedical engineering

Background:

  • ¹⁸F-NaF and ⁹⁹mTc-MDP are common bone imaging agents.
  • Their comparative uptake in bone versus cartilage is not well understood.
  • Direct comparison is needed to guide musculoskeletal molecular imaging.

Purpose of the Study:

  • To directly compare the uptake patterns of ¹⁸F-NaF and ⁹⁹mTc-MDP in bone and cartilage.
  • To evaluate their utility in musculoskeletal molecular imaging.
  • To investigate factors influencing tracer uptake in cartilage.

Main Methods:

  • In vivo and ex vivo radiotracer studies in Sprague-Dawley rats.
  • Quantification of tracer uptake (%ID/g) in bone and cartilage at various time points.
  • Assessment of tracer uptake in viable and devitalized bone/cartilage implants.
  • Histological and autoradiographic analysis.

Main Results:

  • ¹⁸F-NaF exhibited faster blood clearance and higher target-to-background ratios than ⁹⁹mTc-MDP.
  • ¹⁸F-NaF showed higher uptake in cancellous bone, while ⁹⁹mTc-MDP had higher uptake in knee cartilage.
  • Cartilage uptake of ¹⁸F-NaF correlated with cellular activity and calcification, increasing with age.

Conclusions:

  • ¹⁸F-NaF demonstrates distinct, quantifiable cartilage uptake influenced by cellular activity and calcification.
  • ¹⁸F-NaF offers superior imaging characteristics compared to ⁹⁹mTc-MDP for cartilage metabolism.
  • ¹⁸F-NaF is a promising tracer for diagnosing and monitoring bone and joint disorders.