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Updated: Sep 13, 2025

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
Published on: June 8, 2020
Early-Onset Colorectal Cancer: A Review of Current Insights and a Call for Action
Shaina Ailawadi1, David C Kaelber2, Abbinaya Elangovan3
1Department of Internal Medicine, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, OH 44106, USA.
Abstract:
While the incidence of colorectal cancer (CRC) in patients above 50 years old has been decreasing over the last several decades, the incidence of CRC among younger patients has been increasing. Early-onset CRC (EO-CRC) is known to exhibit distinct characteristics including specific genetic mutations and modifiable risk factors, which warrants tailored screening and management approaches. This review synthesizes current insights on EO-CRC's epidemiological, genetic, molecular, and clinical features, as well as a call for action for future research on prevention and clinical management.
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