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Updated: Sep 13, 2025
03:26
Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain
Published on: March 8, 2024
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Targeted Interventional Therapies for the Management of Postamputation Pain: A Comprehensive Review
Dunja Savicevic1, Jovana Grupkovic2, Uros Dabetic2,3
1Special Hospital for Rehabilitation and Orthopedic Prosthetics, 11000 Belgrade, Serbia.
Biomedicines
|July 29, 2025
Summary
Interventional therapies like peripheral nerve stimulation offer promising relief for postamputation pain (PAP), including residual limb pain and phantom limb pain. Further research is needed to optimize these treatments for better long-term outcomes.
Area of Science:
- Pain Management
- Neurology
- Regenerative Medicine
Background:
- Postamputation pain (PAP), encompassing residual limb pain (RLP) and phantom limb pain (PLP), significantly impacts quality of life.
- Current pharmacological treatments often provide inadequate relief for PAP, highlighting the need for alternative strategies.
Purpose of the Study:
- To critically review and synthesize current interventional therapies for PAP.
- To focus on the mechanisms, clinical efficacy, and practical applications of these interventions.
Main Methods:
- A comprehensive literature search was performed across major databases (PubMed, EMBASE, Scopus, Web of Science) for studies published between 2015 and 2025.
- Included articles focused on peripheral nerve interventions and various neuromodulation techniques for PAP management.
Main Results:
- Peripheral interventions (alcohol neurolysis, RFA, CNL) and neuromodulation (SCS, DRG stimulation, CES) show promising results for PAP.
- Peripheral nerve stimulation (PNS) demonstrates favorable safety and efficacy, potentially preventing pain chronification.
Conclusions:
- Contemporary interventional therapies are valuable in the multidisciplinary management of PAP.
- Further research is essential to standardize algorithms, optimize treatment decisions, and enhance long-term outcomes for individuals with PAP.
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