Glucocorticoid Receptor (GR) Expression in Human Tumors: A Tissue Microarray Study on More than 14,000 Tumors
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Glucocorticoid receptor (GR) is frequently expressed in most cancers, appearing in 76.4% of tumors. Reduced GR expression correlates with aggressive features in specific cancer types, indicating context-dependent roles in tumor progression.
Area Of Science
- Oncology
- Molecular Biology
- Genetics
Background
- The glucocorticoid receptor (GR) is a key regulator of gene transcription.
- GR's role in cancer is complex, with proposed oncogenic and tumor-suppressive functions.
- Understanding GR expression patterns is crucial for cancer research.
Purpose Of The Study
- To comprehensively analyze GR expression across a wide spectrum of human cancers.
- To investigate the correlation between GR expression levels and tumor characteristics.
- To elucidate the potential impact of GR on cancer progression.
Main Methods
- Utilized a large tissue microarray (18,527 samples, 147 tumor types).
- Assessed GR expression using immunohistochemistry.
- Correlated GR positivity with clinico-pathological parameters.
Main Results
- GR positivity observed in 76.4% of 14,349 interpretable cancers across all 147 tumor types.
- Strong GR positivity was common, with 77 tumor types showing 100% positivity.
- Reduced GR staining associated with adverse features in urothelial bladder, breast, and clear cell renal cell carcinomas.
Conclusions
- GR expression is a prevalent feature in human malignancies.
- The association between reduced GR and unfavorable tumor features highlights its context-dependent role in cancer.
- GR's functional significance in cancer progression varies by tumor cell of origin.
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.