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Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections
Published on: July 31, 2017
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Sex-Related Differences in Glioblastoma: A Single-Center Retrospective Cohort Study
Chiara Prosperetti1,2, Meltem Yenigün3, Alberto Pagnamenta4
1Neurocenter of Southern Switzerland, Ente Ospedaliero Cantonale, 6900 Lugano, Switzerland.
Biomedicines
|July 29, 2025
Summary
Sex influences glioblastoma (GB) tumor characteristics and treatment. Females show higher multifocality and EGFR amplification, while males receive more chemotherapy and radiotherapy, impacting patient outcomes.
Area of Science:
- Neuro-oncology
- Cancer biology
- Genomics
Background:
- Sex differences impact glioblastoma (GB) epidemiology, biology, and outcomes.
- GB is more common in males, but females often have longer survival.
- Hormonal influences, risk factors, and treatment disparities may explain these differences.
Purpose of the Study:
- To assess sex-based differences in glioblastoma tumor characteristics and patient outcomes.
- To identify predictors of time to progression and mortality in glioblastoma patients.
- To inform personalized treatment strategies by understanding sex-specific patterns.
Main Methods:
- Retrospective analysis of a neuro-oncological database, focusing on glioblastoma (GB) cases.
- Collected data included sex, age, tumor type, molecular biomarkers, and treatment modalities.
- Assessed sex-based differences in tumor features and outcomes; identified mortality and progression predictors.
Main Results:
- No significant sex differences in age or tumor type distribution.
- Females with GB showed higher prevalence of multifocality and EGFR amplification.
- Males received chemotherapy and radiotherapy more frequently; TERT mutation and multifocality predicted poorer outcomes.
Conclusions:
- Sex and molecular profiling are crucial for glioblastoma (GB) management.
- Distinct patterns in tumor characteristics and treatment exist between male and female GB patients.
- Integrating sex-specific considerations and molecular data can improve GB patient outcomes.
Keywords:
glioblastoma and sex differencesglioblastoma epidemiologymolecular biomarkers in gliomaprecision medicine and brain cancersex disparities in brain cancerMore Related Videos
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