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Genomic and Precision Medicine Approaches in Atherosclerotic Cardiovascular Disease: From Risk Prediction to

Andreas Mitsis1, Elina Khattab1, Michaella Kyriakou1

  • 1Cardiology Department, Nicosia General Hospital, State Health Services Organization, 2029 Nicosia, Cyprus.

Biomedicines
|July 29, 2025
PubMed

Insights

Precision medicine advances, including genetic risk scores and gene editing, offer personalized strategies for preventing and treating atherosclerotic cardiovascular disease (ASCVD). These genomic approaches target lipid metabolism for improved patient outcomes.

Area of Science:

  • Genomics
  • Precision Medicine
  • Cardiovascular Disease Research

Background:

  • Atherosclerotic cardiovascular disease (ASCVD) is a major global health concern.
  • Individualized prevention and treatment strategies are increasingly important.
  • Genomic and precision medicine offer novel approaches to ASCVD.

Purpose of the Study:

  • To review recent advances in genomic and precision medicine for ASCVD.
  • To focus on genetic risk scores, lipid metabolism genes, and gene editing.
  • To synthesize findings on therapeutic targets and computational tools.

Main Methods:

  • Conducted a structured literature search of PubMed, Scopus, and Web of Science.
  • Focused on publications from the last decade.
  • Identified key research on genomic mechanisms, therapies, and computational tools.

Main Results:

  • Identified causal genetic variants (e.g., PCSK9, LDLR).
  • Developed polygenic risk scores for early ASCVD prediction.
  • Utilized deep learning for multi-omics analysis.
  • Highlighted PCSK9 inhibitors, RNA-based therapies, and CRISPR gene editing.

Conclusions:

  • Genomic advances promise tailored ASCVD prevention and treatment.
  • Precision medicine can personalize care based on individual genetic profiles.
  • Emerging therapies offer new hope for managing ASCVD.

Keywords:
atherosclerosiscardiovascular diseasegenomicspersonalized therapypharmacogenomicspolygenic risk scoreprecision medicine

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