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Oxidative Stress and Nutritional Antioxidants in Renal Diseases: A Narrative Review

Dorin Dragoș1, Iulia I Enache2, Maria M Manea3

  • 1Faculty of Medicine, Department 1-Medical Semiology, Nephrology-Bucharest Emergency University Hospital, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Antioxidants (Basel, Switzerland)
|July 29, 2025
PubMed

Insights

Natural nutrients show promise in combating oxidative stress, a key factor in kidney disease progression and cardiovascular comorbidities. Further research could lead to new dietary strategies for renal patients.

Area of Science:

  • Nephrology
  • Oxidative Stress Research
  • Nutritional Science

Background:

  • Oxidative stress is integral to the development of numerous kidney disorders, such as acute kidney injury and chronic kidney disease.
  • It also contributes to the link between kidney disease and cardiovascular issues.
  • Even renal replacement therapies may exacerbate oxidative stress in patients.

Purpose of the Study:

  • To review the potential benefits of natural nutrients in managing oxidative stress in renal disease.
  • To highlight promising nutritional components based on preclinical and clinical evidence.
  • To encourage future research into nutritional interventions for kidney patients.

Main Methods:

  • This is a narrative review.
  • It synthesizes existing preclinical and clinical study findings.
  • Focuses on natural nutrients and their impact on oxidative stress pathways.

Main Results:

  • Various natural nutrients have demonstrated potential in preclinical and clinical studies.
  • These nutrients may counteract harmful pathways driven by oxidative stress.
  • Evidence suggests a role for nutrition in mitigating kidney damage.

Conclusions:

  • Natural nutrients offer a promising avenue for supporting patients with renal diseases.
  • Targeting oxidative stress with specific nutrients could be a valuable therapeutic strategy.
  • Further investigation is warranted to establish routine nutritional protocols for kidney health.
Keywords:
acute kidney injuryaging kidneychronic kidney diseaseglomerulopathynatural nutrientsnephrolithiasisoxidative stress

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