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Related Experiment Video

Updated: Sep 13, 2025

Author Spotlight: Advanced Integrated Model for Sepsis-Induced Myopathy and Single-Cell Metabolic Analysis

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Time Matters: Methane Inhalation Mitigates Mitochondrial and Organ Dysfunction in Advanced Experimental Sepsis.

Levente Frigyes Gulácsi¹, Attila Rutai¹, László Juhász¹

¹Institute of Surgical Research, Albert Szent-Györgyi Medical School, University of Szeged, 6720 Szeged, Hungary.

Antioxidants (Basel, Switzerland)

|July 29, 2025

Summary

This summary is machine-generated.

Methane (CH4) inhalation during sepsis improved survival and organ function. This study shows CH4 protects mitochondria and enhances oxygen use, offering potential therapeutic benefits for sepsis patients.

Keywords:

cerebellum fecal peritonitis kidney methane post-treatment oxidative phosphorylation

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Area of Science:

Biomedical research
Sepsis pathophysiology
Mitochondrial function

Background:

Sepsis leads to organ dysfunction, impaired oxygen utilization, and mitochondrial damage.
Current sepsis treatments have limitations in addressing multi-organ failure.

Purpose of the Study:

To investigate the time-dependent effects of methane (CH4) inhalation on organ function, oxygen utilization, and mitochondrial respiration in a rodent sepsis model.
To evaluate CH4's therapeutic potential in sepsis.

Main Methods:

Adult rats underwent sepsis induction or sham operation.
Septic rats received CH4 inhalation at early, intermediate, or late post-insult phases.
Organ function (ROFA score), inflammation (MPO), mitochondrial respiration, and oxygen dynamics were assessed.

Main Results:

Sepsis caused organ dysfunction, reduced oxygen use, and mitochondrial impairment.
Early CH4 improved survival; intermediate CH4 restored cerebellar mitochondrial respiration.
Late CH4 reduced organ dysfunction scores, inflammation, and protected renal/cerebellar mitochondria, improving renal function and oxygenation.

Conclusions:

Targeted methane inhalation during sepsis demonstrates protective effects.
CH4 preserves mitochondrial function, reduces inflammation, and improves systemic oxygen dynamics.
Methane inhalation shows promising therapeutic potential for sepsis management.