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Related Experiment Video

Updated: Sep 13, 2025

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Post-COVID Condition and Neuroinflammation: Possible Management with Antioxidants.

Noemí Cárdenas-Rodríguez1, Iván Ignacio-Mejía2,3, César Miguel Mejía-Barradas3

  • 1Laboratorio de Neurociencias, Instituto Nacional de Pediatriía, Secretariía de Salud, Mexico City 04530, Mexico.

Antioxidants (Basel, Switzerland)
|July 29, 2025
PubMed
Summary

Post-COVID condition (PCC) involves persistent symptoms after SARS-CoV-2 infection. Antioxidant therapies show promise for reducing neuroinflammation and oxidative stress in PCC patients.

Keywords:
antioxidantsneuroinflammationpost-COVID condition

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Area of Science:

  • Neuroscience
  • Immunology
  • Infectious Diseases

Background:

  • Post-COVID condition (PCC) is a complex syndrome with persistent respiratory, neurological, and psychiatric symptoms following SARS-CoV-2 infection.
  • PCC affects women and older adults disproportionately, impacting daily functioning.
  • Pathophysiology involves immune dysregulation, viral persistence, mitochondrial dysfunction, and oxidative stress, leading to neuroinflammation.

Purpose of the Study:

  • To review the clinical features and risk factors of PCC.
  • To examine current evidence on antioxidant-based interventions for PCC.
  • To explore the potential of antioxidants in mitigating neuroinflammation and oxidative damage.

Main Methods:

  • Narrative review of existing literature.
  • Analysis of clinical and experimental data on PCC.
  • Evaluation of antioxidant compounds (vitamins, polyphenols, endogenous antioxidants).

Main Results:

  • Antioxidants demonstrate potential in preclinical and clinical settings for reducing neuroinflammation and oxidative damage.
  • Compounds like vitamins and polyphenols show promise in managing PCC symptoms.
  • Restoring redox balance is a key mechanism by which antioxidants may improve outcomes.

Conclusions:

  • Antioxidant interventions offer a potential therapeutic avenue for Post-COVID condition.
  • Further clinical research is crucial to establish efficacy, safety, and optimal protocols.
  • Targeting neuroinflammation and oxidative stress is vital for managing PCC.