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Related Concept Videos

Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

336
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
336
Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives01:22

Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives

305
Laxatives enhance bowel movements and alleviate constipation. They augment the stool's bulk, stimulate intestinal muscle contractions, draw water into the intestines, or soften the stool. There are five key types of laxatives: bulk laxatives, stimulant laxatives, osmotic laxatives, stool softeners, and lubricant laxatives.
Bulk-forming laxatives, such as psyllium, methylcellulose, and polycarbophil, absorb water in the intestine, increasing stool bulk and promoting bowel movement. This...
305
Drugs for Treatment of Diarrhea-Predominant IBS01:17

Drugs for Treatment of Diarrhea-Predominant IBS

299
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
299
Drugs Affecting GI Tract Motility: Other Laxatives01:20

Drugs Affecting GI Tract Motility: Other Laxatives

463
Laxatives are primarily used to alleviate constipation, a common gastrointestinal disorder characterized by infrequent bowel movements and difficulty passing stools. They work by various mechanisms to increase the volume or frequency of bowel movements. The primary modes of action of laxatives include increasing stool bulk, softening the stool, stimulating intestinal motility, and osmotically drawing water into the intestines.
Osmotic or saline laxatives, like magnesium hydroxide or milk of...
463
Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents01:20

Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents

319
Diarrhea is characterized by the occurrence of frequent, watery bowel movements. Various factors can trigger diarrhea, including viral or bacterial infections, foodborne illnesses, side effects from certain medications, and underlying digestive disorders. If not adequately managed, diarrhea can lead to complications such as dehydration, electrolyte imbalances, and nutrient deficiencies. Severe diarrhea can lead to significant weight loss, malnutrition, and weakened immune function.
Adsorbents...
319
Irritable Bowel Syndrome III: Medical and Nursing Management01:30

Irritable Bowel Syndrome III: Medical and Nursing Management

307
Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
307

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Updated: Sep 13, 2025

Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation
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Current Treatment Options for Children with Functional Constipation-What Is in the Pipeline?

Charlotte A L Jonker1,2,3,4,5, Tirza M van Os1, Ramon R Gorter2,4,5

  • 1Department of Pediatric Gastroenterology and Nutrition, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.

Children (Basel, Switzerland)
|July 29, 2025
PubMed
Summary

Functional constipation (FC) in children is common, affecting 9.5%. New treatments like novel medications and neurostimulation offer hope for therapy-resistant cases, with surgery as a last resort.

Keywords:
functional constipationneurostimulationnew pharmacological approachespediatricssurgery

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Area of Science:

  • Pediatric Gastroenterology
  • Clinical Therapeutics
  • Surgical Interventions

Background:

  • Functional constipation (FC) affects approximately 9.5% of children globally.
  • Initial management combines non-pharmacological and pharmacological approaches.
  • A significant subset of children experience therapy-resistant FC.

Purpose of the Study:

  • To review current insights into the treatment of functional constipation in children.
  • To explore novel pharmacological and non-pharmacological treatment options.
  • To discuss surgical interventions for refractory cases.

Main Methods:

  • Review of current literature on pediatric functional constipation treatments.
  • Analysis of novel pharmacological agents (lubiprostone, prucalopride, linaclotide, plecanatide) based on adult trial data.
  • Evaluation of neurostimulation (posterior tibial nerve stimulation) and surgical options.

Main Results:

  • Novel agents show promise in increasing spontaneous bowel movements.
  • Posterior tibial nerve stimulation demonstrates high satisfaction and a favorable safety profile.
  • Surgical options include botulinum toxin injections, antegrade continence enema, and colonic resection.

Conclusions:

  • Therapy-resistant FC in children is complex and impacts quality of life.
  • An individualized, stepwise approach is crucial for management.
  • Surgical interventions are reserved for severe, refractory cases as a last resort.