Related Experiment Video
Updated: Sep 13, 2025
08:36
Ultrasound Imaging-guided Intracardiac Injection to Develop a Mouse Model of Breast Cancer Brain Metastases Followed by Longitudinal MRI
Published on: March 6, 2014
19.1K
2D Intraoperative Ultrasound in Brain Metastasis Resection: A Matched Cohort Analysis from a Single-Center Experience
Octavian Mihai Sirbu1,2, Alin Chirtes3, Mircea Radu Gorgan1,4
1Clinical Neuroscience Department, Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, Dionisie Lupu Street, No. 37, Sector 2, 020021 Bucharest, Romania.
Cancers
|July 29, 2025
Summary
Intraoperative ultrasound (IOUS) significantly improves gross total resection rates for brain metastases compared to standard neuronavigation. This accessible technology aids in achieving higher resection success, even for larger tumors.
Area of Science:
- Neurosurgery
- Medical Imaging
- Oncology
Background:
- Intraoperative ultrasound (IOUS) is underutilized in brain metastasis surgery.
- Real-time imaging from IOUS can potentially improve surgical outcomes.
- This study compares 2D IOUS to standard neuronavigation for brain metastasis resection.
Purpose of the Study:
- To evaluate the effectiveness of 2D IOUS in enhancing the extent of resection for brain metastases.
- To compare gross total resection (GTR) rates between IOUS-guided surgery and standard neuronavigation.
- To assess the impact of tumor volume on GTR and the role of IOUS in mitigating this effect.
Main Methods:
- Retrospective analysis of 55 adult patients with brain metastases undergoing surgery.
- Two groups: IOUS-guided surgery (n=20) and standard neuronavigation (n=35).
- Gross total resection defined as >96% volumetric resection; statistical analysis included logistic regression and ROC curves.
Main Results:
- GTR >96% achieved in 80% of IOUS cases vs. 42.86% in controls (p=0.008).
- IOUS use significantly increased odds of GTR (OR=5.33, p=0.011).
- IOUS use mitigated the negative impact of larger tumor volume on GTR (interaction OR=1.986, p=0.044).
Conclusions:
- 2D IOUS significantly improves the extent of resection in brain metastasis surgery.
- IOUS facilitates GTR even for larger tumors, offering real-time feedback and low cost.
- Wider adoption of IOUS is recommended in neurosurgical practice, particularly in resource-limited settings.
