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Recurrent vs. Nonrecurrent Superficial Non-Healing Corneal Ulcers in Cats: A Multifactorial Retrospective Analysis
Nuanwan Rujirekasuwan1, Panpicha Sattasathuchana2, Natthanet Sritrakoon1
1Ophthalmology Unit, Faculty of Veterinary Medicine, Kasetsart University Veterinary Teaching Hospital, Kasetsart University, Bangkok 10900, Thailand.
Animals : an Open Access Journal From MDPI
|July 29, 2025
Summary
Recurrent feline corneal ulcers are linked to older cats and underlying systemic illnesses. Early diagnosis and management of these conditions are crucial for preventing ulcer recurrence in cats.
Area of Science:
- Veterinary Ophthalmology
- Feline Medicine
- Ophthalmology Research
Background:
- Feline superficial non-healing corneal ulcers present a clinical challenge due to their persistence and potential for recurrence.
- Individualized treatment strategies are essential for managing these complex ocular lesions in cats.
Purpose of the Study:
- To retrospectively analyze clinical and treatment-related factors contributing to the recurrence of feline superficial non-healing corneal ulcers.
- To identify key differences between recurrent and nonrecurrent cases to inform future treatment protocols.
Main Methods:
- A retrospective study of 136 feline eyes with superficial non-healing corneal ulcers (113 nonrecurrent, 23 recurrent).
- Data collected included patient age, breed, ulcer location, treatment modalities, healing times, and concurrent conditions.
- Statistical analysis was performed to identify significant associations with ulcer recurrence.
Main Results:
- Recurrent ulcers were significantly more common in older cats (p=0.026).
- Domestic Shorthairs were the most affected breed. Recurrent cases required more intensive management and longer healing times.
- Higher rates of concurrent viral (p<0.001) and bacterial/fungal infections (p=0.027) were observed in recurrent cases, along with increased use of oral lysine (p=0.049) and famciclovir (p=0.016).
Conclusions:
- Feline superficial non-healing corneal ulcer recurrence is associated with advanced age and systemic health issues.
- Prompt diagnosis and comprehensive management of underlying viral and microbial infections are critical for successful treatment and prevention of recurrence.
