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Updated: Sep 13, 2025

Depletion and Reconstitution of Macrophages in Mice
Published on: August 1, 2012
The Role of Macrophage-Derived Netrin-1 in Inflammatory Diseases
Yi Wu1,2, Zhiying Liu1,2, Peiqi Xu1,2
1Department of Laboratory Medicine, Jiangsu Province Engineering Research Center for Precise Diagnosis and Treatment of Inflammatory Diseases, The Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China.
Abstract:
Macrophages are multifunctional immune cells distributed throughout the whole body, and they have functions in antigen presentation, phagocytosis, killing, and immune regulation. As the most widely studied molecule in the netrin family, netrin-1 plays a key role in neuronal navigation, angiogenesis, and cell survival. Macrophage-derived netrin-1 not only regulates neurovascular regeneration through ligand-receptor binding but also influences macrophage phenotypes by modulating polarization, thereby achieving the purpose of promoting or repairing disease damage. In this review, we will summarize the recent research advances on the role of macrophage-derived netrin-1 and its receptors in a variety of inflammatory diseases and cancers.
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