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Quiescence Multiverse.
Damien Laporte1, Isabelle Sagot1
1CNRS, Institut de Biochimie et Génétique Cellulaires, UMR5095, Université de Bordeaux, 33077 Bordeaux, France.
Biomolecules
|July 29, 2025
Summary
Cellular quiescence, a reversible pause in cell division, is influenced by time. Time deepens quiescence and creates cell population heterogeneity, enhancing resilience.
Area of Science:
- Cell Biology
- Molecular Biology
- Physiology
Background:
- Cellular quiescence is a temporary, reversible cessation of cell proliferation.
- Most cells spend significant portions of their lifespan in a quiescent state, awaiting proliferative signals.
- Quiescent cells must maintain viability and the ability to re-enter the cell cycle over time.
Purpose of the Study:
- To explore the intricate relationship between time and cellular quiescence.
- To discuss how time influences the survival and proliferative capacity of quiescent cells.
- To examine the mechanisms by which time generates heterogeneity within quiescent cell populations.
Main Methods:
- This review synthesizes existing literature on cellular quiescence and time.
- It discusses deterministic factors and stochastic events impacting quiescent cells.
- The review analyzes how time affects the deepening of quiescence and exit dynamics.
Main Results:
- Time impacts quiescent cells through both deterministic and stochastic processes.
- Quiescence deepens over time, extending the exit process.
- Time generates heterogeneity in quiescent cell populations, increasing robustness.
Conclusions:
- The interplay between quiescence and time is complex, involving feedback loops.
- Time-induced heterogeneity is crucial for the resilience of quiescent cell populations.
- Understanding these dynamics is key to comprehending cell fate decisions.
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