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Updated: Sep 13, 2025

Basic Research in Plasma Medicine - A Throughput Approach from Liquids to Cells
Published on: November 17, 2017
Therapeutic Plasma Exchange: Current and Emerging Applications to Mitigate Cellular Signaling in Disease
R M Imtiaz Karim Rony1,2, Alireza Shokrani1,2, Naseeb Kaur Malhi1,2
1Department of Diabetes Complications, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.
None:
Therapeutic plasma exchange (TPE) is a blood purification technique which functions to remove pathological plasma constituents such as autoantibodies, inflammatory cytokines, immune complexes, and extracellular vesicles (EVs) that contribute to a range of disease states. In this review, we examine current and emerging indications for TPE across cardiovascular, metabolic, neurological, inflammatory, and oncological diseases. We cover emerging preclinical animal models and new applications, emphasizing the roles of cellular signaling and EV biology in mediating plasma functions, and discuss unique therapeutic "windows of opportunity" offered by TPE. We conclude that TPE is underutilized in both preventative and precision medicine, and that next generation TPE therapies will involve personalized plasma biomarker and modulation feedback, with synergistic plasma infusion therapies to mitigate age associated disease and promote tissue rejuvenation.
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