Related Experiment Video
Updated: Sep 13, 2025
10:41
An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
Published on: April 5, 2018
10.5K
PHF20L1: An Epigenetic Regulator in Cancer and Beyond
Yishan Wang1, Qin Hu1,2, Haixia Zhao1
1Zhejiang Key Laboratory of Imaging and Interventional Medicine, The Fifth Affliated Hospital of Wenzhou Medical University, Lishui 323000, China.
Biomolecules
|July 29, 2025
Summary
Plant homeodomain finger protein 20-like 1 (PHF20L1) is an epigenetic reader involved in cancer. Upregulation of PHF20L1 drives tumor progression and immune evasion, suggesting it as a therapeutic target.
Area of Science:
- Epigenetics
- Molecular Biology
- Oncology
Background:
- Plant homeodomain (PHD) finger protein 20-like 1 (PHF20L1) is an epigenetic reader.
- It recognizes histone post-translational modifications (PTMs) through its Tudor and PHD finger domains.
- PHF20L1 regulates chromatin remodeling, DNA repair, and oncogene transcription.
Purpose of the Study:
- To review the role of PHF20L1 in various cancers.
- To elucidate the molecular mechanisms of PHF20L1 in cancer pathogenesis.
- To propose novel therapeutic strategies targeting PHF20L1.
Main Methods:
- Comprehensive literature review.
- Analysis of PHF20L1's role in breast, ovarian, colorectal cancers, and retinoblastomas.
- Investigation of PHF20L1's interaction with epigenetic complexes.
Main Results:
- PHF20L1 is upregulated in multiple malignancies.
- PHF20L1 promotes cancer proliferation, metastasis, and immune evasion.
- PHF20L1 interacts with key epigenetic complexes to orchestrate gene expression.
Conclusions:
- PHF20L1 is a key driver of tumor progression across various cancers.
- Targeting PHF20L1 with small-molecule inhibitors offers a potential precision treatment strategy.
- Further research into PHF20L1's regulatory networks is crucial for developing targeted therapies.
Related Concept Videos
01:37Epigenetic Regulation
3.1K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
3.1K
02:23Abnormal Proliferation
4.6K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.6K
02:38Mitogens and the Cell Cycle
6.9K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.9K
01:23Negative Regulator Molecules
36.0K
Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
36.0K
02:04Covalently Linked Protein Regulators
7.2K
Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
These groups modify specific amino acids in a protein....
7.2K
02:23Master Transcription Regulators
7.1K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
7.1K