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Updated: Sep 13, 2025
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Isolation, Characterization, and Total DNA Extraction to Identify Endophytic Fungi in Mycoheterotrophic Plants
Published on: May 5, 2023
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Antibacterial Compounds Isolated from Endophytic Fungi Reported from 2021 to 2024
Humberto E Ortega1,2,3, Daniel Torres-Mendoza1,2,4, Luis Cubilla-Rios1,2,3
1Departamento de Química Orgánica, Facultad de Ciencias Naturales, Exactas y Tecnología, Universidad de Panamá, Panamá 0824, Panama.
Antibiotics (Basel, Switzerland)
|July 29, 2025
Summary
Endophytic fungi yield novel antibacterial compounds crucial for fighting drug-resistant bacteria. Some compounds show antibiotic-like activity, offering potential for new drug development.
Area of Science:
- Mycology
- Pharmacology
- Natural Products Chemistry
Background:
- Endophytic fungi are a vital source of unique bioactive compounds.
- Antibiotic resistance in pathogenic bacteria is a major global health concern.
- Novel antibiotic discovery is essential to combat resistant infections.
Purpose of the Study:
- To review antibacterial compounds from endophytic fungi reported between January 2021 and December 2024.
- To identify key fungal genera and plant sources for these compounds.
- To assess the potential of these compounds as future antibiotics.
Main Methods:
- Literature review of scientific papers published from January 2021 to December 2024.
- Analysis of 132 antibacterial compounds derived from endophytic fungi.
- Identification of frequently reported fungal genera (e.g., Aspergillus, Penicillium) and host plants.
- Evaluation of biological activity data for selected compounds.
Main Results:
- 132 antibacterial compounds from endophytic fungi were identified.
- Aspergillus and Penicillium were the most common fungal genera.
- Medicinal plants were the primary hosts, and rice was a common culture medium.
- A portion of the compounds demonstrated biological activity comparable to existing antibiotics.
Conclusions:
- Endophytic fungi continue to be a promising source for discovering novel antibacterial agents.
- Compounds from genera like Aspergillus and Penicillium warrant further investigation.
- These natural products may serve as lead structures for developing new antibiotics or combination therapies.
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