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Multisite Infections Caused by Carbapenem-Resistant Klebsiella Pneumoniae: Unveiling the Clinical Characteristics and

Jing Li1, Shunjun Wu1, Huanhuan Zhang1

  • 1Department of Respiratory and Critical Care Medicine, Xijing Hospital of Air Force Medical University, Xi'an 710032, China.

Antibiotics (Basel, Switzerland)
|July 29, 2025
PubMed

Insights

Carbapenem-resistant Klebsiella pneumoniae multisite infections (CRKP MSI) are associated with higher mortality. Previous surgery and ICU admission increase CRKP MSI risk, while ICU admission, high Pitt bacteremia scores, and thrombocytopenia predict mortality.

Area of Science:

  • Infectious Diseases
  • Clinical Microbiology
  • Epidemiology

Background:

  • Limited research exists on multisite infections (MSIs) caused by carbapenem-resistant Klebsiella pneumoniae (CRKP).
  • CRKP poses a significant threat due to its resistance to carbapenem antibiotics.
  • Understanding CRKP MSI characteristics and risk factors is crucial for patient management.

Purpose of the Study:

  • To determine the clinical characteristics of CRKP multisite infections (MSIs).
  • To identify risk factors associated with CRKP MSI development.
  • To investigate risk factors for mortality in patients with CRKP MSI.

Main Methods:

  • Retrospective study of 101 patients with CRKP bloodstream infection (BSI) from January 2017 to December 2021.
  • Analysis of demographic, clinical, microbiological, therapeutic, and outcome data.
  • Multivariate analysis to evaluate independent risk factors for CRKP MSI and mortality.

Main Results:

  • 74.3% of patients had CRKP MSI; the overall case fatality rate was 42.6%.
  • Independent risk factors for CRKP MSI included previous surgery (OR 3.971) and ICU admission (OR 3.322).
  • Independent risk factors for mortality were ICU admission (OR 4.765), Pitt bacteremia score > 4 (OR 3.820), and thrombocytopenia (OR 8.650).

Conclusions:

  • CRKP MSIs are associated with significantly poorer clinical outcomes and higher mortality rates.
  • Identifying patients at high risk for CRKP MSI and mortality is essential for improving prognosis.
  • Early screening and intervention strategies are vital for managing CRKP MSI.
Keywords:
carbapenem resistantklebsiella pneumoniaemortalitymultisite infectionsrisk factors

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