Related Experiment Video
Updated: Sep 13, 2025

Quantification of Information Encoded by Gene Expression Levels During Lifespan Modulation Under Broad-range Dietary Restriction in C. elegans
Published on: August 16, 2017
Improving the Minimum Free Energy Principle to the Maximum Information Efficiency Principle
Chenguang Lu1,2
1Intelligence Engineering and Mathematics Institute, Liaoning Technical University, Fuxin 123000, China.
This study introduces Semantic Variational Bayesian (SVB) and Maximum Information Efficiency (MIE) principles, offering a more robust framework than the original Minimum Free Energy Principle (FEP) for understanding brain and behavior coordination with the environment.
Area of Science:
- Neuroscience
- Information Theory
- Computational Biology
Background:
- The Minimum Free Energy Principle (FEP) by Friston, based on Variational Bayesian (VB) methods, suggests the brain and behavior self-organize with the environment.
- FEP has theoretical limitations, including potential misunderstandings and constraints limited to likelihood functions.
Purpose of the Study:
- To address FEP's limitations by introducing Semantic Variational Bayesian (SVB) and the Maximum Information Efficiency (MIE) principle.
- To provide a more comprehensive framework for understanding brain-environment interactions and active inference.
Main Methods:
- Introduction of the semantic information G theory and the R(G) function, utilizing a P-T probability framework.
- Application of logical Bayesian Inference and analysis of the R(G) function.
- Theoretic analysis and computing experiments to validate the proposed SVB and MIE principles.
Main Results:
- Demonstration that R - G = F - H(X|Y), where F is Variational Free Energy (VFE) and H(X|Y) is Shannon conditional entropy, challenging the notion of continuously decreasing F.
- SVB is shown to be a reliable and straightforward method for latent variable analysis and active inference.
- Clarification of the relationships between Shannon information, semantic information, VFE, free energy, exergy, and conditional entropy in different thermodynamic systems.
Conclusions:
- SVB and MIE offer advancements over FEP, providing a more nuanced understanding of information processing in biological systems.
- The proposed principles enhance the interpretability and applicability of free energy principles.
- Integration with deep learning methods is suggested for broader applications of the MIE principle.
Related Concept Videos
The Carnot Cycle
What could be the theoretical limit to the efficiency of a heat engine? The...
Gibbs Free Energy and Thermodynamic Favorability
Gibbs Free Energy
Entropy Change in Reversible Processes
The statement can be further generalized to prove that entropy is a state function. Take a cyclic process between any two points on a p-V diagram.
Entropy within the Cell
Entropy and the Second Law of Thermodynamics
The relation between entropy and disorder can be illustrated with the example of the phase change of ice to water. In ice, the molecules are located at specific sites giving a solid state, whereas, in a liquid form, these molecules are much freer to move. The molecular arrangement has therefore become more randomized. Although the change in average...

