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[Clinico-experimental studies of therapy optimization in kidney tuberculosis]
Zeitschrift Fur Urologie Und Nephrologie
|September 1, 1985
Summary
Short-term chemotherapy for extrapulmonary tuberculosis is viable. Both isoniazid (INH) and rifampicin (RMP) reach effective concentrations in kidney tuberculosis lesions, proving no terrain-specific limitations.
Area of Science:
- Pharmacology
- Nephrology
- Infectious Diseases
Background:
- Extrapulmonary tuberculosis treatment often avoids short-term chemotherapy due to presumed site-specific challenges.
- Investigating drug distribution in renal tuberculosis is crucial for optimizing treatment.
Purpose of the Study:
- To determine the distribution and concentration of isoniazid (INH) and rifampicin (RMP) in kidney tuberculosis lesions.
- To radiometrically assess drug concentrations directly within the tuberculous renal focus.
Main Methods:
- Tritium labeling of INH and RMP for radiometrical measurement.
- Clinical and experimental investigation of drug distribution in tuberculous kidneys.
Main Results:
- Both INH (300 mg IV) and RMP (600 mg PO) achieved antimycobacterially effective concentrations in extensively destroyed kidneys.
- Drug concentrations in tuberculous renal caverns consistently exceeded the minimum inhibitory concentration.
- No significant terrain-specific peculiarities were found for tuberculous kidneys.
Conclusions:
- Optimized antitubercular chemotherapy is suitable for renal tuberculosis, without terrain-based restrictions.
- Findings likely extend to other forms of extrapulmonary tuberculosis.
- The developed radiometric method offers high precision and potential application in cancer chemotherapy research.