A Technological Review of Digital Twins and Artificial Intelligence for Personalized and Predictive Healthcare

Digital transformation is reshaping the healthcare field by streamlining diagnostic workflows and improving disease management. Within this transformation, Digital Twins (DTs), which are virtual representations of physical systems continuously updated by real-world data, stand out for their ability to capture the complexity of human physiology and behavior. When coupled with Artificial Intelligence (AI), DTs enable data-driven experimentation, precise diagnostic support, and predictive modeling without posing direct risks to patients. However, their integration into healthcare requires careful consideration of ethical, regulatory, and safety constraints in light of the sensitivity and nonlinear nature of human data. In this review, we examine recent progress in DTs over the past seven years and explore broader trends in AI-augmented DTs, focusing particularly on movement rehabilitation. Our goal is to provide a comprehensive understanding of how DTs bolstered by AI can transform healthcare delivery, medical research, and personalized care. We discuss implementation challenges such as data privacy, clinical validation, and scalability along with opportunities for more efficient, safe, and patient-centered healthcare systems. By addressing these issues, this review highlights key insights and directions for future research to guide the proactive and ethical adoption of DTs in healthcare.