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Related Experiment Video

Updated: Sep 13, 2025

Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases

Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases

Published on: May 2, 2025

From Adipose to Action: Reprogramming Stem Cells for Functional Neural Progenitors for Neural Regenerative Therapy.

Junjie Peng^1,2, Zhu Zhang^1,2,3, Min Li^1,2,3

¹Teaching and Research Division, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong SAR, China.

International Journal of Molecular Sciences

|July 29, 2025

Summary

Adipose-derived stem cells (ADSCs) can be converted into neural stem cell-like cells (iNSCs) for treating Parkinson's disease (PD). This approach offers a promising alternative to neural stem cells for neural repair and regenerative medicine.

Keywords:

Parkinson’s disease adipose-derived stem cells induced neural stem cell-like cells regenerative medicine stem cell therapy

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Generation of Induced Neural Stem Cells from Peripheral Mononuclear Cells and Differentiation Toward Dopaminergic Neuron Precursors for Transplantation Studies

Generation of Induced Neural Stem Cells from Peripheral Mononuclear Cells and Differentiation Toward Dopaminergic Neuron Precursors for Transplantation Studies

Published on: July 11, 2019

Area of Science:

Regenerative Medicine
Neuroscience
Stem Cell Biology

Background:

Neural stem cells show potential for treating neurodegenerative diseases like Parkinson's disease (PD) but face clinical hurdles.
Adipose-derived stem cells (ADSCs) offer advantages in accessibility, multipotency, and low immunogenicity for regenerative medicine.

Purpose of the Study:

To systematically review the biological characteristics, induction protocols, molecular mechanisms, and applications of ADSCs in neural repair.
To explore the potential of induced neural stem cell-like cells (iNSCs) derived from ADSCs for PD treatment.

Main Methods:

Literature review and systematic summary of existing research on ADSCs and iNSCs.
Analysis of induction protocols, molecular mechanisms, and biological characteristics of ADSCs for neural differentiation.

Main Results:

ADSCs can be induced into iNSCs, presenting a viable strategy for restoring dopaminergic neuron populations in PD.
Current challenges include optimizing differentiation protocols and ensuring functional integration of transplanted cells.

Conclusions:

ADSC-derived iNSCs hold significant potential for advancing personalized and combination therapies for neurodegenerative diseases.
Future research directions include leveraging biomaterials and gene editing to enhance ADSC-based regenerative therapies.