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Microbiome-Based Products: Therapeutic Potential for Inflammatory Skin Diseases
Anamarija Rušanac1,2, Zara Škibola1,2, Mario Matijašić1,2
1Department of Intercellular Communication, Center for Translational and Clinical Research, School of Medicine, University of Zagreb, Šalata 2, 10000 Zagreb, Croatia.
International Journal of Molecular Sciences
|July 29, 2025
Summary
Maintaining a healthy skin microbiota is key for skin health. Microbiome-based interventions like probiotics show promise for managing inflammatory skin conditions by restoring microbial balance.
Area of Science:
- Dermatology and Microbiology
- Investigates the role of the skin microbiome in health and disease.
Background:
- Skin microbiota balance is crucial for skin health.
- Dysbiosis, or microbial imbalance, is linked to inflammatory skin conditions like atopic dermatitis, acne, psoriasis, and rosacea.
- Advances in sequencing technologies enhance understanding of skin microbial communities.
Purpose of the Study:
- To explore the potential of microbiome-based interventions for managing inflammatory skin diseases.
- To highlight novel therapeutic strategies targeting the skin ecosystem.
Main Methods:
- Utilizes high-throughput sequencing and metagenomic analyses to study skin microbial communities.
- Reviews current and emerging microbiome-based therapeutic approaches.
Main Results:
- Microbiome-based products (probiotics, prebiotics, postbiotics, live biotherapeutics) offer targeted modulation of the skin ecosystem.
- These interventions can enhance beneficial microbes, suppress pathogens, and improve immune tolerance.
- Demonstrates potential for preventing, managing, and potentially reversing inflammatory skin conditions.
Conclusions:
- Microbiome-based strategies represent a promising therapeutic avenue for inflammatory skin disorders.
- Further research, clinical validation, and regulatory frameworks are necessary to realize their full potential.
- These novel approaches offer a targeted alternative to conventional therapies, potentially reducing side effects and resistance.
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