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Cardiomyopathy III: Hypertrophic Cardiomyopathy

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...

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Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization

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Integrated MicroRNA-mRNA Sequencing Analysis Identifies Regulators and Networks Involved in Feline Hypertrophic

Jessica Joshua^1,2, Jeff L Caswell², Anja Kipar³

¹Department of Clinical Studies, Ontario Veterinary College, University of Guelph, 50 Stone Road East, Guelph, ON N1G 2W1, Canada.

International Journal of Molecular Sciences

|July 29, 2025

Summary

This summary is machine-generated.

This study reveals molecular mechanisms behind feline hypertrophic cardiomyopathy (HCM), identifying key microRNAs and pathways involved in cardiac remodeling and homeostasis in cats.

Keywords:

HCM angiogenesis atrium cat fibrosis heart inflammation pathway remodeling ventricle

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Area of Science:

Cardiology
Molecular Biology
Genomics

Background:

Feline hypertrophic cardiomyopathy (HCM) pathogenesis and cardiac remodeling mechanisms remain incompletely understood.
Investigating molecular underpinnings is crucial for understanding feline heart disease.

Purpose of the Study:

To elucidate microRNA-mRNA interactions and regulatory networks in feline HCM.
To identify upstream regulators and molecular pathways implicated in cardiac remodeling in feline HCM.

Main Methods:

Utilized left ventricle (LV) and left atrium (LA) mRNA and microRNA sequencing from cats with HCM and controls.
Analyzed microRNA-mRNA interactions, regulatory networks, and upstream regulators.
Identified key molecular pathways, including those related to inflammation, fibrosis, and cellular changes.

Main Results:

Identified TNFα, IL1β, and TGFβ as upstream regulators in HCM LV and LA.
Discovered specific microRNAs (e.g., miR-132, miR-124-3p, miR-146-5p) and molecules (e.g., FGF23, THBS4) associated with HCM.
Observed activated macrophage pathways and highlighted the HIF1α signaling pathway in HCM LV, suggesting potential cardioprotective mechanisms.

Conclusions:

This research provides novel insights into the molecular pathogenesis of feline HCM.
Identified key factors and pathways involved in both disease development and the maintenance of cardiac homeostasis in feline hearts.