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Related Experiment Video

Updated: Sep 13, 2025

Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies

Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies

Published on: January 31, 2025

Circulating Extracellular Vesicles in Cardiovascular Disease.

Ilenia Pia Cappucci¹, Elena Tremoli¹, Barbara Zavan²

¹Maria Cecilia Hospital, GVM Care and Research, 48033 Cotignola, Italy.

International Journal of Molecular Sciences

|July 29, 2025

Summary

This summary is machine-generated.

Extracellular vesicles (EVs) are key players in cardiovascular disease (CVD) intercellular communication. This review explores their roles in CVD, potential as biomarkers, and therapeutic applications for precision medicine.

Keywords:

atherosclerosis biomarkers cardiovascular disease exosomes extracellular vesicles heart failure hypertension miRNA microparticles myocardial infarction

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Characterizing Extracellular Vesicles from Biological Fluids

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Published on: February 28, 2025

Area of Science:

Cardiovascular Research
Cell Biology
Biomarker Discovery

Background:

Cardiovascular disease (CVD) is a major global health concern requiring advanced strategies.
Extracellular vesicles (EVs) mediate intercellular communication, impacting cardiovascular pathophysiology.
EVs carry bioactive molecules and are released by various cardiovascular cell types.

Purpose of the Study:

To review the multifaceted roles of EVs in cardiovascular disease (CVD).
To highlight the potential of EVs as diagnostic and prognostic biomarkers for CVD.
To discuss emerging EV-based therapeutic strategies for cardiovascular conditions.

Main Methods:

Literature review of studies on extracellular vesicles and cardiovascular disease.
Analysis of EV composition (miRNAs, proteins, lipids) and cellular origins.
Examination of current and future applications of EVs in CVD diagnosis and therapy.

Main Results:

EVs significantly influence vascular remodeling, inflammation, and immune responses in CVD.
Circulating EVs show promise as non-invasive biomarkers for CVD diagnosis and prognosis.
Engineered EVs offer potential for targeted drug delivery in treating cardiovascular diseases like atherosclerosis and myocardial infarction.

Conclusions:

EVs are critical mediators in cardiovascular disease (CVD) and hold significant potential for precision medicine.
Standardization of EV isolation and characterization is crucial for clinical translation.
Further research into EV roles and applications can advance cardiovascular care.