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Related Experiment Videos

Changes in computed tomographic findings in microprolactinomas before and after bromocriptine.

R Demura, O Kubo, H Demura

    Acta Endocrinologica
    |November 1, 1985
    PubMed
    Summary

    Computed tomography (CT) effectively diagnosed microprolactinoma, with bromocriptine treatment shrinking tumors and often causing empty sella. Enhanced CT scans aided diagnosis and monitored treatment response.

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    Area of Science:

    • Endocrinology
    • Radiology
    • Oncology

    Background:

    • Microprolactinoma, a common pituitary tumor, presents diagnostic challenges.
    • Bromocriptine is a standard treatment for hyperprolactinemia associated with microprolactinoma.

    Purpose of the Study:

    • To evaluate the utility of computed tomography (CT) in diagnosing microprolactinoma.
    • To assess the effects of bromocriptine treatment on pituitary tumor size and density using CT.

    Main Methods:

    • Computed tomography (CT) scans of the pituitary were performed on 10 patients with microprolactinoma before and after bromocriptine treatment.
    • Sagittal reconstruction images were utilized for enhanced visualization.

    Main Results:

    • Intrapituitary low densities, indicative of microprolactinoma, were observed in 70% of patients before treatment.

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  • Bromocriptine treatment led to shrinkage and increased density of these low densities, correlating with normalized plasma prolactin levels.
  • Empty sella was observed in treated patients and some untreated controls.

    • Conclusions:

    • Enhanced CT scans, particularly with sagittal reconstruction, are valuable for diagnosing microprolactinoma.
    • Bromocriptine effectively reduces microprolactinoma size and can induce empty sella formation.