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Long Non-Coding RNAs in Psoriasis and Cutaneous Squamous Cell Carcinoma.

Ioana Irina Trufin1,2, Loredana Ungureanu1,3, Salomea-Ruth Halmágyi1

  • 1Department of Dermatology, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania.

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Long non-coding RNAs (lncRNAs) are key regulators in skin inflammation and cancer. Dysregulated lncRNAs in psoriasis and cutaneous squamous cell carcinoma suggest shared pathways, offering potential diagnostic and therapeutic targets.

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Area of Science:

  • Dermatology
  • Molecular Biology
  • Oncology

Background:

  • Long non-coding RNAs (lncRNAs) are crucial regulators of skin disorders.
  • They influence gene expression, immune responses, and epidermal homeostasis.
  • lncRNAs show potential as diagnostic, prognostic, and therapeutic targets in skin diseases.

Purpose of the Study:

  • To investigate the role of lncRNAs in both psoriasis and cutaneous squamous cell carcinoma (cSCC).
  • To identify overlapping pathogenic mechanisms between these two skin conditions.
  • To explore the potential of lncRNAs as biomarkers and therapeutic targets.

Main Methods:

  • Literature search focusing on lncRNAs implicated in psoriasis and cSCC.
  • Analysis of dysregulated lncRNA expression patterns.
  • Highlighting shared molecular pathways and functions.

Main Results:

  • Several lncRNAs (e.g., HOTAIR, MALAT-1, H19, uc.291) are dysregulated in both psoriasis and cSCC.
  • These lncRNAs impact keratinocyte proliferation, apoptosis, immune modulation, and cytokine signaling.
  • Overlapping functions suggest a role in the transition from inflammation to carcinogenesis.

Conclusions:

  • lncRNA dysregulation links chronic inflammation in psoriasis to skin carcinogenesis.
  • Understanding these pathways provides insights into disease susceptibility.
  • Further functional studies and clinical validation are necessary for therapeutic development.