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Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
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Long Non-Coding RNAs in Psoriasis and Cutaneous Squamous Cell Carcinoma
Ioana Irina Trufin1,2, Loredana Ungureanu1,3, Salomea-Ruth Halmágyi1
1Department of Dermatology, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania.
Journal of Clinical Medicine
|July 29, 2025
Summary
Long non-coding RNAs (lncRNAs) are key regulators in skin inflammation and cancer. Dysregulated lncRNAs in psoriasis and cutaneous squamous cell carcinoma suggest shared pathways, offering potential diagnostic and therapeutic targets.
Area of Science:
- Dermatology
- Molecular Biology
- Oncology
Background:
- Long non-coding RNAs (lncRNAs) are crucial regulators of skin disorders.
- They influence gene expression, immune responses, and epidermal homeostasis.
- lncRNAs show potential as diagnostic, prognostic, and therapeutic targets in skin diseases.
Purpose of the Study:
- To investigate the role of lncRNAs in both psoriasis and cutaneous squamous cell carcinoma (cSCC).
- To identify overlapping pathogenic mechanisms between these two skin conditions.
- To explore the potential of lncRNAs as biomarkers and therapeutic targets.
Main Methods:
- Literature search focusing on lncRNAs implicated in psoriasis and cSCC.
- Analysis of dysregulated lncRNA expression patterns.
- Highlighting shared molecular pathways and functions.
Main Results:
- Several lncRNAs (e.g., HOTAIR, MALAT-1, H19, uc.291) are dysregulated in both psoriasis and cSCC.
- These lncRNAs impact keratinocyte proliferation, apoptosis, immune modulation, and cytokine signaling.
- Overlapping functions suggest a role in the transition from inflammation to carcinogenesis.
Conclusions:
- lncRNA dysregulation links chronic inflammation in psoriasis to skin carcinogenesis.
- Understanding these pathways provides insights into disease susceptibility.
- Further functional studies and clinical validation are necessary for therapeutic development.
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