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A Disintegrin and Metalloprotease 15 (ADAM15) as a Potential Predictor of Distant Metastasis in Colorectal Cancer (CRC)

  • 0Department of Biochemical Diagnostics, Medical University, 15-269 Białystok, Poland.
Journal of Clinical Medicine +

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July 29, 2025

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July 29, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Serum ADAM15 levels may aid in diagnosing colorectal cancer (CRC) and predicting metastasis. Combining ADAM15 with CEA and CRP shows promise for improved CRC diagnosis.

Area Of Science

  • Oncology
  • Biochemistry
  • Molecular Biology

Background

  • A disintegrin and metalloprotease 15 (ADAM15) is implicated in colorectal cancer (CRC) progression by promoting tumor growth and modulating the tumor microenvironment.
  • Elevated ADAM15 expression is observed in primary tumors, suggesting its potential role in CRC pathogenesis.

Purpose Of The Study

  • To investigate serum ADAM15 concentrations as a potential biomarker for CRC diagnosis and progression.
  • To compare serum ADAM15 levels with established tumor markers (CEA, CA19-9) and an inflammation marker (CRP) in CRC patients.

Main Methods

  • Serum concentrations of ADAM15, CEA, and CA19-9 were measured using immunoenzyme assays in 110 CRC patients and 54 healthy volunteers.
  • C-reactive protein (CRP) levels were assessed using the turbidimetric method.
  • Diagnostic characteristics of all tested proteins were evaluated.

Main Results

  • Serum ADAM15, CEA, and CA19 levels were higher in CRC patients than in healthy controls, with CEA showing significant difference (p < 0.001).
  • ADAM15 concentrations were significantly elevated in CRC patients with distant metastases compared to those without (p = 0.043).
  • Combined analysis of ADAM15 and CRP achieved the highest diagnostic sensitivity (89%).

Conclusions

  • ADAM15 plays a significant role in CRC pathogenesis and can predict the presence of distant metastases.
  • Measuring serum ADAM15, particularly in conjunction with CEA and CRP, may enhance the diagnostic accuracy for CRC patients.

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