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Related Experiment Video

Updated: Sep 13, 2025

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Ectopic Intramural Isthmic Pregnancy: Case Report.

Eloisa Maria Mariani1, Diletta Guglielmi1,2, Paola Camponovo1,2

  • 1Obstetrics and Gynecology, IRCCS San Gerardo dei Tintori Foundation, 20900 Monza, Italy.

Journal of Clinical Medicine
|July 29, 2025
PubMed
Summary

Intramural pregnancy (IMP), a rare ectopic pregnancy, can be managed non-surgically. This case study shows successful conservative treatment preserving fertility.

Keywords:
Methotrexate (MTX)ectopic pregnancy (EP)fertility preservationintramural pregnancyuterine artery embolization (UAE)

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Area of Science:

  • Reproductive Medicine
  • Gynecology
  • Ectopic Pregnancy

Background:

  • Intramural pregnancy (IMP) is a rare ectopic pregnancy implantation within the uterine myometrium.
  • IMP poses significant risks including hemorrhage and uterine rupture.
  • Early diagnosis via ultrasound is crucial for management decisions.

Observation:

  • A 35-year-old patient with a history of in vitro fertilization (IVF) presented with diagnosed intramural pregnancy.
  • The IMP was located in the back-isthmian region of the uterus.
  • The patient was clinically stable and desired future fertility.

Findings:

  • A conservative treatment approach was employed, including mifepristone and ultrasound-guided intracavitary methotrexate.
  • Uterine artery embolization was deferred due to arterial anastomoses.
  • Successful, progressive reabsorption of the gestational sac occurred over 8 months.

Implications:

  • Non-surgical management is a viable option for select intramural pregnancy cases.
  • Conservative treatment can preserve future fertility in patients with IMP.
  • This approach highlights the importance of individualized treatment for rare ectopic pregnancies.