Exploring Multi-Organ Crosstalk via the TissUse HUMIMIC Chip System: Lessons Learnt So Far

Area of Science:

• Biomedical Engineering
• Cell Biology
• Toxicology

Background:

• Three-dimensional (3D) in vitro cell culture models replicate the in vivo environment.
• Organ-on-a-chip systems have evolved into multiorgan-on-chip systems to study inter-organ communication (crosstalk).
• Multiorgan interactions are crucial for metabolic, inflammatory, and tissue repair processes.

Purpose of the Study:

• To provide an overview of multiorgan systems.
• To summarize studies utilizing the TissUse HUMIMIC system for multiorgan crosstalk research.
• To update the field of multiorgan microphysiological systems.

Main Methods:

• Review of existing literature on multiorgan-on-chip systems.
• Focus on studies employing the TissUse HUMIMIC Starter and Chip microphysiological system.
• Analysis of applications in cellular, molecular, and toxicology studies.

Main Results:

• The TissUse HUMIMIC system facilitates study of crosstalk between organs like gut-liver, liver-brain, and liver-kidney.
• These models are applied in various research areas, including drug development and toxicology.
• The use of these systems aids in reducing animal testing in research.

Conclusions:

• Multiorgan-on-chip systems, particularly the TissUse HUMIMIC, are valuable tools for studying complex human physiological interactions.
• These advanced in vitro models contribute to a better understanding of inter-organ crosstalk.
• The technology supports the development of new therapies and toxicological assessments while promoting ethical research practices.