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Association between Systemic Immune-Inflammation Index (SII) and secondary haemorrhage risk after tonsillectomy
Murat Gümüşsoy1, Özlem Yagız Agayarov1, İbrahim Çukurova1
1Department of Otolaryngology Head and Neck Surgery, University of Health Sciences, Izmir Tepecik Training and Research Hospital, Izmir, Turkey.
The Journal of Laryngology and Otology
|July 29, 2025
Summary
The Systemic Immune-Inflammation Index may help predict the risk of secondary tonsillar hemorrhage after tonsillectomy. Higher index values were observed in patients experiencing bleeding, indicating its potential as an inflammatory marker.
Area of Science:
- Otolaryngology
- Pediatric Surgery
- Inflammatory Markers
Background:
- Secondary tonsillar hemorrhage is a common complication following tonsillectomy.
- Identifying reliable predictors for post-tonsillectomy hemorrhage is crucial for patient management.
Purpose of the Study:
- To evaluate the relationship between the Systemic Immune-Inflammation Index (SII) and secondary tonsillar hemorrhage in pediatric patients.
- To determine if SII can serve as a predictive marker for post-tonsillectomy bleeding.
Main Methods:
- A comparative analysis was conducted on 60 pediatric patients with secondary hemorrhage and 60 controls without bleeding.
- Laboratory parameters, including SII values, were collected preoperatively, on the day of bleeding, and on a control day for comparison.
Main Results:
- Patients with secondary hemorrhage exhibited significantly higher neutrophil counts and SII values on the tonsillectomy day compared to controls (p < 0.001).
- During hemorrhage, platelet and neutrophil counts, along with SII, increased, while lymphocyte counts decreased (p < 0.001).
- Neutrophil counts and SII remained significantly elevated in the hemorrhage group even on the control day (p < 0.001).
Conclusions:
- The Systemic Immune-Inflammation Index is a novel inflammatory marker that shows promise in predicting the risk of post-tonsillectomy hemorrhage.
- Elevated SII levels may indicate an increased susceptibility to secondary bleeding after tonsillectomy.
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