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Updated: Sep 13, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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DCAF16-Based Covalent Degradative Handles for the Modular Design of Degraders

Lauren M Orr1,2,3, Sydney J Tomlinson4,5,3, Hannah R Grupe1,2,3

  • 1Department of Chemistry. University of California, Berkeley, Berkeley, California 94720, United States.

ACS Central Science
|July 29, 2025
PubMed
Summary

Researchers developed a novel covalent degradative handle that enables targeted protein degradation. This versatile handle can be applied to various ligands, facilitating the degradation of challenging targets like BRD4 and the androgen receptor (AR) for therapeutic development.

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