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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
Published on: September 9, 2012
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Risk Factors for Recurrent Thrombosis in Patients with Antiphospholipid Syndrome-A Single-Centre Cohort Study
Natali Karandyszowska1,2, Francesca Faustini3, Hevgin Alagündüz1
1Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
Summary
Thrombocytopenia and chronic kidney disease are key risk factors for recurrent thrombosis in antiphospholipid syndrome (APS). Optimizing anticoagulation is crucial for preventing these dangerous events.
Area of Science:
- Cardiovascular Medicine
- Hematology
- Rheumatology
Background:
- Recurrent thrombosis is a significant clinical challenge for patients with antiphospholipid syndrome (APS).
- Limited data exist on the specific risk factors contributing to recurrent thrombotic events in APS due to its rarity.
Purpose of the Study:
- To investigate the association between cardiovascular (CV) and APS-related risk factors and recurrent thrombosis.
- To evaluate the utility of the adjusted Global Antiphospholipid Syndrome Score (aGAPSS) in predicting recurrent thrombosis.
Main Methods:
- A retrospective cohort study of 250 APS patients at Karolinska University Hospital (2014-2020).
- Cox proportional hazard models and logistic/Poisson regression were used to analyze risk factors and recurrent thrombosis.
- Multiple thrombotic events per patient were included in the analysis.
Main Results:
- Thrombocytopenia significantly increased the risk of recurrent thrombosis (HR 2.57).
- Chronic kidney disease (CKD) was associated with an increased probability of recurrence (OR 2.55).
- Each point increase in aGAPSS correlated with a 10% higher risk of recurrent thrombosis (HR 1.10). Inadequate anticoagulation was a trigger in nearly 25% of recurrences.
Conclusions:
- Thrombocytopenia is a confirmed major risk factor for recurrent thrombosis in APS.
- Chronic kidney disease requires closer attention in risk assessment for APS patients.
- While aGAPSS shows association, further evaluation is needed; improving anticoagulation is essential to reduce recurrence.
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