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Updated: Sep 13, 2025
04:33
Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
Published on: April 26, 2024
801
Causal Relationship Between Depression, Sleep Disorders, and Constipation: A Mendelian Randomization and Mediation
Jun-Xi Wang1, Kai-Yan Wei2, Wei Lin1
1Endoscope Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, People's Republic of China.
Psychology Research and Behavior Management
|July 29, 2025
Summary
This study reveals a causal link between depression and constipation, with sleep disorders acting as a partial mediator. Targeting sleep disturbances may help manage depression-related constipation.
Area of Science:
- Genetics
- Epidemiology
- Psychiatry
Background:
- Depression and constipation are common conditions with complex etiologies.
- The relationship between depression and constipation is not fully understood, and potential mediating factors require investigation.
Purpose of the Study:
- To investigate the causal relationship between depression, sleep disorders, and constipation.
- To evaluate the mediating role of sleep disorders in the association between depression and constipation using Mendelian randomization (MR).
Main Methods:
- Utilized genome-wide association study (GWAS) data for depression, sleep disorders, and constipation.
- Employed multivariable Mendelian randomization (MR) and mediation MR analysis with inverse-variance weighted (IVW) as the primary method.
- Conducted sensitivity analyses to ensure the robustness of the findings.
Main Results:
- Confirmed a significant causal effect of depression on constipation (OR 1.26, P=0.00034).
- Found no significant causal effect of constipation on depression (P=0.086).
- Demonstrated that sleep disorders significantly mediate the depression-constipation link, accounting for 13% of the association.
Conclusions:
- Established a causal relationship between depression and constipation.
- Identified sleep disorders as a significant partial mediator in this association.
- Suggests sleep disturbances as a potential therapeutic target for depression-related constipation.
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