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Published on: February 28, 2019
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Sinonasal Cancers: Single Center Experience.
Elif Sertesen Camoz1, Ozturk Ates1, Caner Kilic2
1University of Health Sciences, Dr. Abdurrahman Yurtaslan Ankara Training and Research Hospital, Medical Oncology, 06200 Yenimahalle, Ankara, Turkey.
Summary
Sinonasal cancers (SNCs) are rare, often diagnosed late. Local recurrence and intracranial extension negatively impact survival, highlighting the need for multidisciplinary management and further research.
Area of Science:
- Otolaryngology
- Oncology
- Head and Neck Surgery
Background:
- Sinonasal cancers (SNCs) are rare and heterogeneous, frequently diagnosed at advanced stages due to nonspecific symptoms.
- Effective management necessitates a multidisciplinary approach, integrating various specialties for optimal patient outcomes.
Purpose of the Study:
- To report the management experience of sinonasal cancers at a tertiary care center.
- To analyze prognostic factors influencing survival and recurrence in SNCs.
Main Methods:
- Retrospective study of 26 patients diagnosed with SNCs.
- Staging according to the American Joint Committee on Cancer (AJCC) 8th edition criteria.
- Analysis of treatment modalities including chemotherapy, surgery, and chemoradiotherapy, with a median follow-up of 56 months.
Main Results:
- Majority of patients were male (76.9%) with maxillary sinus (80.8%) and squamous cell histology (65.5%) being predominant.
- Advanced T4 tumors (61.5%) were common at diagnosis, with a local recurrence rate of 23.1%.
- Local recurrence (p=0.037) and intracranial extension (p=0.019) were identified as adverse prognostic factors for overall survival and disease-free survival, respectively.
Conclusions:
- Sinonasal cancers require a comprehensive, multidisciplinary management strategy due to their rarity and heterogeneity.
- Late diagnosis and advanced stage at presentation are significant challenges.
- Further prospective studies are essential to refine treatment protocols and improve patient care for SNCs.
