Congenital Desmoid Tumor of the Larynx: A Therapeutic Challenge

Desmoid tumors affecting vital structures can be life-threatening despite their non-malignant behavior. The lack of standardized treatment poses a therapeutic challenge, particularly regarding the sequelae in pediatric patients. A one-month-old male patient presented with respiratory distress and stridor. Endoscopic exploration and computed tomography revealed a laryngeal tumor, which was confirmed as a desmoid tumor via biopsy. Systemic chemotherapy in combination with imatinib was initiated, leading to stabilization of the tumor size. A surgical approach for desmoid tumors may be unsuitable for pediatric patients due to excessive morbidity. In such cases, targeted therapies like tyrosine kinase inhibitors can effectively control the disease.