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Research progress of liposomal bupivacaine and its value in perioperative pain management
Hongli Sun1, Yapeng Lu1, Yingbin Wang1
1Department of Anesthesiology, Lanzhou University Second Hospital, No. 82 Cuiyingmen, Chengguan District, Lanzhou, Gansu Province, 730030, China.
Abstract:
In current pain management practices, multimodal analgesia strategies centered on regional nerve blocks, combined with low-dose opioids and adequate nonsteroidal anti-inflammatory drugs, are considered the standard approach. However, the short-lived effectiveness of conventional local anesthetics leads to inadequate postoperative pain management, which substantially diminishes patient comfort and satisfaction during recovery periods. Prolonging the duration of local anesthetics has become a core focus of regional anesthesia research, with liposomal bupivacaine gaining attention due to its ultra-long-acting properties. This article aims to systematically explore the mechanism of action, safety, potential adverse reactions, and clinical applications of liposomal bupivacaine in nerve blocks and surgical procedures, providing a scientific basis for optimizing clinical analgesia strategies.
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