Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ultra-Sensitive Wireless Capacitive Nanocomposite-Based Pressure Sensors for Health Monitoring.

Advanced materials technologies·2026
Same author

Highly Stable Quasi-Solid-State Sodium Batteries via Facile Grain Boundary Engineering.

ACS applied materials & interfaces·2026
Same author

Behavioral relevance of category selectivity revealed by human ECoG data.

PloS one·2025
Same author

Development and evaluation of gluconic acid-targeted liposomal doxorubicin for enhanced anti-tumor activity in colon cancer.

Journal of pharmaceutical sciences·2025
Same author

Enhancing the immunomodulatory osteogenic properties of Ti-Mg alloy by Mg<sup>2+</sup>-containing nanostructures.

Regenerative biomaterials·2024
Same author

Protective effects of betanin, a novel acetylcholinesterase inhibitor, against H<sub>2</sub>O<sub>2</sub>-induced apoptosis in PC12 cells.

Molecular biology reports·2024
Same journal

High-turnover copper-catalyzed amination of aryl bromides: exploring catalyst and ligand degradation pathways.

RSC advances·2026
Same journal

Sb-based metal oxide and sulfide anode materials for alkali-ion batteries.

RSC advances·2026
Same journal

Directed evolution of a cytochrome P450 monooxygenase for improved perillyl alcohol biosynthesis <i>via</i> a tailored genetically encoded biosensor.

RSC advances·2026
Same journal

Superspin-glass dynamics and magnetic memory in ZnFe<sub>2</sub>O<sub>4</sub> nanoparticles synthesized <i>via</i> a green egg-white-assisted route.

RSC advances·2026
Same journal

Porous and luminescent Dy-doped Co-BTC MOFs for label-free detection of tetracycline and vanadium traces in water.

RSC advances·2026
Same journal

An optimized green simultaneous HPLC analysis of dissolution rate monitoring for valsartan and sacubitril in tablet medications.

RSC advances·2026
See all related articles

Related Experiment Video

Updated: Sep 13, 2025

Insertion of Flexible Neural Probes Using Rigid Stiffeners Attached with Biodissolvable Adhesive
06:40

Insertion of Flexible Neural Probes Using Rigid Stiffeners Attached with Biodissolvable Adhesive

Published on: September 27, 2013

14.9K

Designing parylene coating for implantable brain-machine interfaces.

Saman Ebrahimibasabi1, Maryam Golshahi2, Naghmeh Shahraki2

  • 1Materials Science and Engineering, School for Engineering of Matter, Transport and Energy, Arizona State University Tempe AZ 85287 USA hamed.arami@asu.edu.

RSC Advances
|July 29, 2025
PubMed
Summary
This summary is machine-generated.

Researchers optimized parylene coatings for implantable brain-machine interfaces (BMIs) by combining adhesion promoters and heat treatments. This improved coating stability and adhesion, crucial for long-term device performance and biocompatibility.

More Related Videos

Chronic Implantation of Multiple Flexible Polymer Electrode Arrays
08:54

Chronic Implantation of Multiple Flexible Polymer Electrode Arrays

Published on: October 4, 2019

10.9K
Tools for Surface Treatment of Silicon Planar Intracortical Microelectrodes
06:39

Tools for Surface Treatment of Silicon Planar Intracortical Microelectrodes

Published on: June 8, 2022

2.5K

Related Experiment Videos

Last Updated: Sep 13, 2025

Insertion of Flexible Neural Probes Using Rigid Stiffeners Attached with Biodissolvable Adhesive
06:40

Insertion of Flexible Neural Probes Using Rigid Stiffeners Attached with Biodissolvable Adhesive

Published on: September 27, 2013

14.9K
Chronic Implantation of Multiple Flexible Polymer Electrode Arrays
08:54

Chronic Implantation of Multiple Flexible Polymer Electrode Arrays

Published on: October 4, 2019

10.9K
Tools for Surface Treatment of Silicon Planar Intracortical Microelectrodes
06:39

Tools for Surface Treatment of Silicon Planar Intracortical Microelectrodes

Published on: June 8, 2022

2.5K

Area of Science:

  • Biomaterials Science
  • Neuroengineering
  • Surface Chemistry

Background:

  • Parylene is a promising material for encapsulating implantable bioelectronics due to its biocompatibility and chemical stability.
  • A major limitation of parylene is its poor adhesion to inorganic substrates, hindering long-term device reliability.
  • Enhancing parylene adhesion is critical for developing robust implantable brain-machine interfaces (BMIs).

Purpose of the Study:

  • To investigate pre- and post-deposition treatments to improve parylene coating adhesion and stability for implantable BMIs.
  • To determine the optimal conditions for adhesion promotion and heat treatment.
  • To evaluate the impact of optimized coatings on device performance and biocompatibility.

Main Methods:

  • Utilized varying concentrations of 3-(trimethoxysilyl)propyl-methacrylate as an adhesion promoter.
  • Applied post-deposition heat treatments at different temperatures.
  • Assessed coating stability using accelerated aging tests at 87 °C for 7 days.
  • Evaluated cytotoxicity and in vivo biocompatibility.
  • Performed FTIR and EDS analyses to characterize chemical changes.
  • Conducted numerical analysis to assess the effect on electrical performance.

Main Results:

  • Optimal adhesion and stability were achieved with a 150 °C heat treatment and appropriate adhesion promoter concentration.
  • Heat treatment increased parylene crystallinity, improving chemical stability and reducing delamination and microcracks.
  • Higher adhesion promoter concentrations enhanced adhesion, particularly at 150 °C.
  • Parylene coating preserved and enhanced wireless coupling in implantable devices.
  • Optimized parylene coatings demonstrated improved in vivo brain compatibility and cell viability.

Conclusions:

  • Synergistic pre- and post-deposition treatments significantly enhance parylene adhesion and stability for implantable BMIs.
  • Optimized parylene coatings improve device reliability, electrical performance, and biocompatibility.
  • This study provides a systematic approach to optimizing parylene encapsulation for advanced neurotechnologies.