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Using Machine Learning to Identify Ophthalmology Subspecialty Care and Advance Workforce Research with the IRIS®
Ju Hyun Jeon1, Ju-Yeun Lee1,2,3, Tobias Elze4
1Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.
Ophthalmology Science
|July 29, 2025
Summary
Machine learning accurately identifies ophthalmology subspecialists using the American Academy of Ophthalmology
Area of Science:
- Ophthalmology
- Machine Learning
- Health Informatics
Background:
- The American Academy of Ophthalmology's IRIS® Registry (Intelligent Research in Sight) contains deidentified patient data.
- Classifying ophthalmologists into subspecialties is crucial for workforce research and policy.
- Current methods for subspecialty identification may not be efficient or scalable.
Purpose of the Study:
- To develop and evaluate machine learning models for identifying ophthalmology subspecialists.
- To classify ophthalmologists into general and subspecialty categories using practice data.
- To assess the performance of different machine learning approaches for subspecialty classification.
Main Methods:
- Utilized deidentified data from 9032 ophthalmologists in the IRIS Registry (2013-2023).
- Employed random forest models for binary and multispecialty classification based on diagnosis, procedure, and prescription codes.
- Assessed model performance using area under the receiver operating characteristic curve (AUROC), F1 scores, and Matthews correlation coefficient.
Main Results:
- Machine learning models achieved high accuracy in identifying ophthalmology subspecialists.
- Retina (AUROC: 0.981) and oculofacial (AUROC: 0.975) subspecialties showed the highest classification accuracy.
- The procedure-only random forest model demonstrated superior performance (AUROC: 0.903) compared to diagnosis-only or prescription-only models.
Conclusions:
- Machine learning models utilizing IRIS Registry data can provide near real-time assessment of ophthalmic subspecialty care.
- Identifying subspecialty physicians through practice patterns offers insights into eye care delivery trends.
- These findings have implications for ophthalmic workforce research and policy development.

