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Updated: Sep 13, 2025

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
Published on: July 14, 2015
Data Synthesis Reinvented: Preserving Missing Patterns for Enhanced Analysis
Xinyue Wang1, Hafiz Asif2, Shashank Gupta3
1Renmin University, Beijing, China.
None:
Synthetic data is being widely used as a replacement or enhancement for real data in fields as diverse as healthcare, telecommunications, and finance. Unlike real data, which represents actual people and objects, synthetic data is generated from an estimated distribution that retains key statistical properties of the real data. This makes synthetic data attractive for sharing while addressing privacy, confidentiality, and autonomy concerns. Real data often contains missing values that hold important information about individual, system, or organizational behavior. Standard synthetic data generation methods eliminate missing values as part of their pre-processing steps and thus completely ignore this valuable source of information. Instead, we propose methods to generate synthetic data that preserve both the observable and missing data distributions; consequently, retaining the valuable information encoded in the missing patterns of the real data. Our approach handles various missing data scenarios and can easily integrate with existing data generation methods. Extensive empirical evaluations on diverse datasets demonstrate the effectiveness of our approach as well as the value of preserving missing data distribution in synthetic data.
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